Perhexiline maleate ( WSM 3978G )

产品货号. M15566 CAS No. 6724-53-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Perhexiline maleate
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Perhexilinemaleate (WSM 3978G) 是一种预防性抗心绞痛药，可抑制肉碱棕榈酰转移酶 (CPT1/CPT2)。
产品描述

Perhexiline maleate (WSM 3978G) is a prophylactic antianginal agent that inhibits carnitine palmitoyltransferase (CPT1/CPT2); promotes HER3 ablation through receptor internalization and inhibits tumor growth; activates KLF14 and reduces atherosclerosis by modulating ApoA-I production.Hypertension Phase 2 Clinical.
体外实验

Cell Viability Assay Cell Line:HepG2 cells Concentration:5, 10, 15, 25 μM Incubation Time:2, 4, 6 h Result:Induced time- and concentration-dependent cytotoxicity in hepatic cells.Western Blot Analysis Cell Line:HepG2 cells Concentration:5, 10, 15, 25 μM Incubation Time:2 h Result:Reduced Bcl-2 and Mcl-1 level, and increased Bad level.
体内实验

Animal Model:Orthotopic glioblastoma mouse modelDosage:80 mg/kg Administration:Oral gavage, for 3 days. Result:Reduces tumor size (MR imaging) and improves in overall survival.
同义词

WSM 3978G
通路

Others
靶点

Other Targets
受体

Other Targets
研究领域

Cardiovascular Disease
适应症

Hypertension

1. Guo Y, et al. J Clin Invest. 2015 Oct 1;125(10):3819-30. 2. Hamdan M, et al. Pharmacol Res. 2001 Aug;44(2):99-104.

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