Perhexiline maleate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Perhexilinemaleate (WSM 3978G) 是一种预防性抗心绞痛药，可抑制肉碱棕榈酰转移酶 (CPT1/CPT2)。

Perhexiline maleate (WSM 3978G) is a prophylactic antianginal agent that inhibits carnitine palmitoyltransferase (CPT1/CPT2); promotes HER3 ablation through receptor internalization and inhibits tumor growth; activates KLF14 and reduces atherosclerosis by modulating ApoA-I production.Hypertension Phase 2 Clinical.

Cell Viability Assay Cell Line:HepG2 cells Concentration:5, 10, 15, 25 μM Incubation Time:2, 4, 6 h Result:Induced time- and concentration-dependent cytotoxicity in hepatic cells.Western Blot Analysis Cell Line:HepG2 cells Concentration:5, 10, 15, 25 μM Incubation Time:2 h Result:Reduced Bcl-2 and Mcl-1 level, and increased Bad level.

Animal Model:Orthotopic glioblastoma mouse modelDosage:80 mg/kg Administration:Oral gavage, for 3 days. Result:Reduces tumor size (MR imaging) and improves in overall survival.

WSM 3978G

Others

Other Targets

Other Targets

Cardiovascular Disease

Hypertension

6724-53-4

393.568

C23H39NO4

>98% (HPLC)

In Vitro:?Ethanol : 25 mg/mL (63.52 mM)

C1CCC(CC1)C(CC2CCCCN2)C3CCCCC3.C(=CC(=O)O)C(=O)O

2-(2,2-dicyclohexylethyl)-piperidine maleate

(-20℃)

With Ice Pack

≥ 2 years